Description
Product Characteristics:
Description: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Gene: CHP2
Target Information: cofactor for catalysis of the electroneutral exchange of Na+ and H+ mediated by the Na+/H+ exchanger (NHE) family of membrane proteins [RGD, Feb 2006]